Today we honor the life and legacy of Clement J. McDonald, MD, who passed away on May 21, 2026.
Known worldwide as the one and only "Clem", he was a luminary in the field of biomedical informatics. Clem was a titan, world renowned for his innovations in electronic medical records, clinical decision support, multi-institution health data exchange, and especially in the global standards that enable computers to share and understand health data.
As a co-founder and life-long member of HL7 International, Clem's vision for interoperability enabled by consensus standards is encoded in our DNA.
A Pioneering Career
Clem grew up on Chicago's West Side, graduated from Notre Dame in three years, and attended the University of Illinois College of Medicine. He completed his internal medicine residency at Cook County Hospital and the University of Wisconsin, after which he joined Indiana University and the Regenstrief Institute in 1972. There he built one of the world's first electronic medical record systems and published the first randomized controlled trials demonstrating that computerized clinical decision support could improve care.
He rose through the academic ranks at the Indiana University School of Medicine to become Distinguished Professor of Medicine and the Sam Regenstrief Professor of Medical Informatics, and served as Director of the Regenstrief Institute from 1990 to 2006. He also developed the Indiana Network for Patient Care, a groundbreaking statewide health information exchange. Throughout this time, he also practiced primary care internal medicine in a safety-net clinic for more than 25 years (that ran on the EMR he created).
In 2004, Clem joined the U.S. National Library of Medicine where he first served as Director of the Lister Hill National Center for Biomedical Communications and Scientific Director of its intramural research program, and later serving as Chief Health Data Standards Officer — a position he held until his passing.